Learn how H2 Blockers, such as famotidine in PEPCID® products, help provide lasting heartburn relief and lower the amount of acid your stomach produces. Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. PEPCID® is the original famotidine brand and, for 35 years, has been effective and safe acid reducer when used as directed. PEPCID® is clinically proven to provide heartburn relief and is backed by 50+ clinical studies. Pepcid (famotidine): H2 blocker for heartburn/GERD and ulcers. OTC/Rx dosing, onset, interactions, side effects, and prices by country. Pepcid (Famotidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Famotidine (Pepcid and Zantac) treats conditions that cause too much stomach acid, like heartburn, stomach ulcers and reflux disease. Prevent & relieve heartburn with Maximum Strength PEPCID AC® tablets with famotidine. Our strongest acid control formula helps control stomach acid all day or all night. Famotidine (Pepcid) is a type of acid reducer called a histamine-2 (H2) antagonist. It helps treat problems caused by too much stomach acid. Over-the-counter famotidine (Pepcid or Pepcid AC) can help with heartburn in people who are 12 and up. Pepcid is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Pepcid is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Overview: Famotidine is used to treat heartburn, ulcers, and other conditions caused by too much stomach acid. It is available by prescription and over-the-counter (OTC). Famotidine is an H2.